MDM2 Ab
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MDM2 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
MDM2 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
MDM2 Ab
MDM2 Ab
MDM2 Ab
MDM2 Ab
MDM2 Ab
MDM2 Ab
MDM2 Ab
MDM2 Ab
MDM2 Ab
MDM2 Ab

产品简介

Product Introduction

Catalog No.

CY9046

Source

Recombinant Rabbit mAb

UniProt ID

Q00987

Reactivity

Human;Mouse;Rat

Application

WB

Calculated Mol Weight

55 kDa

Observed Mol Weight

90 kDa

Recommended Dilution

WB 1:1000-1:2000

Alternative Names

E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human MDM2

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53.

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CY9046

Specifications：

50μl, 147μl

Price：

$188/50μl, $368/147μl

Delivery time：

1-1 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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