Sestrin 1 Ab
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Sestrin 1 Ab
Western blot analysis of SESN1 expression in K562 cell lysate.
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab

产品简介

Product Introduction

Catalog No.

CY8334

Source

Recombinant Rabbit mAb

UniProt ID

Q9Y6P5

Reactivity

Human;Mouse;Rat

Application

WB;FC

Calculated Mol Weight

57 kDa

Observed Mol Weight

70 kDa

Recommended Dilution

WB 1:1000-1:2000

FC 1:20-1:100

Alternative Names

PA26; sesn1; SEST1; sestrin 1;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human Sestrin 1

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway.

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CY8334

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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