CDKN2A Ab
Instructions

Copy product information

CDKN2A Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
CDKN2A Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
CDKN2A Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
CDKN2A Ab
Western blot analysis of CDKN2A/p14ARF expression in PC3 cell lysate.
CDKN2A Ab
Immunofluorescent analysis using the Antibody at 1:50 dilution.
CDKN2A Ab
CDKN2A Ab
CDKN2A Ab

产品简介

Product Introduction

Catalog No.

CY8312

Source

Recombinant Rabbit mAb

UniProt ID

Q8N726

Reactivity

Human

Application

WB;ICC/IF;IP;FC

Calculated Mol Weight

14 kDa

Observed Mol Weight

14 kDa

Recommended Dilution

WB 1:1000-1:2000

ICC/IF 1:50-1:200

IP 1:20-1:50

FC 1:20-1:100

Alternative Names

ARF; CDK4I; CDKN2; CDKN2A; CMM2; INK4; INK4a; MLM; MTS1; p14; p14ARF;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human CDKN2A

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.

引用文献

Citation

Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication

期刊名称：

PLoS Pathogens

PMID：

38394330

影响因子：

5.5

应用范围：

WB

检测物种：

Pig

发表时间：

2024-02-23

用户反馈

User feedback

用户评论
用户名：
评论内容：
评论时间：
回复内容:
回复时间：
上一页
下一页
页码：
总页数：
总行数：
首页
尾页
CY8312

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

Click here

>> All antibody products targeting this target

>> All rabbit monoclonal antibody products targeting this target