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Product Introduction
Catalog No.
Source
UniProt ID
Reactivity
Application
Calculated Mol Weight
Observed Mol Weight
Recommended Dilution
WB 1:1000-1:2000
IHC 1:100-1:200
ICC/IF 1:50-1:200
IHF 1:50-1:200
FC 1:20-1:100
Alternative Names
BKSR1; dKsr; EK31; KSR; KSR1; RSU2; SR31;
Host
Isotype
Clonality
Modification
Immunogen
Purification
Concentration
Buffer System
Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Condition
Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.
Description
Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases.Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2.
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