CDK4 Ab
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CDK4 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
CDK4 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
CDK4 Ab
Western blot analysis of CDK4 expression in Hela cell lysate.
CDK4 Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
CDK4 Ab
Immunohistochemical analysis of paraffin-embedded human stomach cancer, using CDK4 Antibody.
CDK4 Ab
Immunofluorescent analysis of MCF7 cells, using CDK4 Antibody.
CDK4 Ab
CDK4 Ab

产品简介

Product Introduction

Catalog No.

CY5827

Source

Recombinant Rabbit mAb

UniProt ID

P11802

Reactivity

Human

Application

WB;IHC;ICC/IF;IHF;FC

Calculated Mol Weight

34 kDa

Observed Mol Weight

34 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

ICC/IF 1:50-1:200

IHF 1:50-1:200

FC 1:20-1:100

Alternative Names

Cyclin-dependent kinase 4; Cell division protein kinase 4; PSK-J3; PSKJ3; CDK4; CMM 3;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human CDK4

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase.

引用文献

Citation

ElncRNA1, a long non-coding RNA that is transcriptionally induced by oestrogen, promotes epithelial ovarian cancer cell proliferation

期刊名称：

INTERNATIONAL JOURNAL OF ONCOLOGY

PMID：

28714515

影响因子：

3.079

应用范围：

WB

检测物种：

Human

发表时间：

2017-06-07
LncRNA LINC01088 inhibits the function of trophoblast cells, activates the MAPK-signaling pathway and associates with recurrent pregnancy loss

期刊名称：

MOLECULAR HUMAN REPRODUCTION

PMID：

34264302

影响因子：

4.025

应用范围：

WB

检测物种：

Human

发表时间：

2021-07-15
HSF1 activates the FOXO3a–ΔNp63α–CDK4 axis to promote head and neck squamous cell carcinoma cell proliferation and tumour growth

期刊名称：

FEBS LETTERS

PMID：

36700826

影响因子：

3.5

应用范围：

WB,IHC

检测物种：

Mouse,Human

发表时间：

2023-01-26
MicroRNA-668-3p inhibits myoblast proliferation and differentiation by targeting Appl1

期刊名称：

BMC GENOMICS

PMID：

37488537

影响因子：

4.4

应用范围：

WB

检测物种：

Mouse

发表时间：

2023-07-24
Eicosapentaenoic acid-mediated activation of PGAM2 regulates skeletal muscle growth and development via the PI3K/AKT pathway

期刊名称：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

PMID：

38641281

影响因子：

7.7

应用范围：

WB

检测物种：

Pig

发表时间：

2024-04-17

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CY5827

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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