ASC Ab
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ASC Ab
Western blot analysis of TMS1 expression in U937 cell lysate.
ASC Ab
Immunofluorescent analysis using the Antibody at 1:50 dilution.
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab

产品简介

Product Introduction

Catalog No.

CY5689

Source

Recombinant Rabbit mAb

UniProt ID

Q9ULZ3

Reactivity

Human

Application

WB;ICC/IF;FC

Calculated Mol Weight

22 kDa

Observed Mol Weight

22 kDa

Recommended Dilution

WB 1:1000-1:2000

ICC/IF 1:50-1:200

FC 1:20-1:100

Alternative Names

PYCARD; ASC; CARD5; TMS; TMS-1; TMS1;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human ASC

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Functions as a key mediator in apoptosis and inflammation.Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner.Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3.

引用文献

Citation

Regulation of NLRP3 inflammasome by CD38 through cADPR-mediated Ca2+ release in vascular smooth muscle cells in diabetic mice

期刊名称：

LIFE SCIENCES

PMID：

32407845

影响因子：

3.647

应用范围：

WB,IHC,ICC/IF

检测物种：

Mouse

发表时间：

2020-05-11
Empagliflozin ameliorates vascular calcification in diabetic mice through inhibiting Bhlhe40-dependent NLRP3 inflammasome activation

期刊名称：

ACTA PHARMACOLOGICA SINICA

PMID：

38172306

影响因子：

6.9

应用范围：

ICC/IF

检测物种：

Mouse

发表时间：

2024-01-03
FGF21 overexpression alleviates VSMC senescence in diabetic mice by modulating the SYK-NLRP3 inflammasome-PPARγ-catalase pathway: FGF21 alleviates high glucose-induced VSMC senescence

期刊名称：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA

PMID：

38733164

影响因子：

3.3

应用范围：

ICC/IF,WB

检测物种：

Mouse

发表时间：

2024-05-10
Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway

期刊名称：

BMC Cardiovascular Disorders

PMID：

38992615

影响因子：

2

应用范围：

IHC,WB,ICC/IF

检测物种：

Mouse

发表时间：

2024-07-12
Sodium Tanshinone IIA Sulfonate alleviates vascular senescence in diabetic mice by modulating the A20-NFκB-NLRP3 inflammasome-catalase pathway

期刊名称：

Scientific Reports

PMID：

39085294

影响因子：

3.8

应用范围：

ICC/IF,WB,IHC

检测物种：

Mouse

发表时间：

2024-07-26

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CY5689

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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