p63 Ab
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p63 Ab
p63 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
p63 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
p63 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
p63 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
p63 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
p63 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
p63 Ab
Western blot analysis of p63 expression in A431 cell lysate.

产品简介

Product Introduction

Catalog No.

CY5659

Source

Recombinant Rabbit mAb

UniProt ID

Q9H3D4

Reactivity

Human;Mouse;Rat

Application

WB;IHC;ICC/IF;IHF;FC

Calculated Mol Weight

77 kDa

Observed Mol Weight

35-77 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

ICC/IF 1:50-1:200

IHF 1:50-1:200

FC 1:20-1:100

Alternative Names

EEC3; KET; LMS; SHFM4; TA p63 alpha; TP63; p51; p73H; p73L; tumor protein p63;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human p63

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2.

引用文献

Citation

Atypical GATA transcription factor TRPS1 represses gene expression by recruiting CHD4/NuRD(MTA2) and suppresses cell migration and invasion by repressing TP63 expression

期刊名称：

Oncogenesis

PMID：

30563971

影响因子：

4.722

应用范围：

WB

检测物种：

Human

发表时间：

2018-12-19
E47 upregulates ΔNp63α to promote growth of squamous cell carcinoma

期刊名称：

Cell Death & Disease

PMID：

33833226

影响因子：

8.469

应用范围：

WB,IHC

检测物种：

Human

发表时间：

2021-04-08
HSF1 activates the FOXO3a–ΔNp63α–CDK4 axis to promote head and neck squamous cell carcinoma cell proliferation and tumour growth

期刊名称：

FEBS LETTERS

PMID：

36700826

影响因子：

3.5

应用范围：

WB,IHC

检测物种：

Mouse,Human

发表时间：

2023-01-26

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CY5659

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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