APC Ab
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APC Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
APC Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
APC Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
APC Ab
Western blot analysis of APC expression in 293T cell lysate.
APC Ab
Immunohistochemical analysis of paraffin-embedded human colon cancer, using APC Antibody.
APC Ab
APC Ab
APC Ab

产品简介

Product Introduction

Catalog No.

CY5641

Source

Recombinant Rabbit mAb

UniProt ID

P25054

Reactivity

Human;Mouse;Rat

Application

WB;IHC;ICC/IF;IHF;IP

Calculated Mol Weight

312 kDa

Observed Mol Weight

170 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

ICC/IF 1:50-1:200

IHF 1:50-1:200

IP 1:20-1:50

Alternative Names

APC; APC protein; Adenomatous polyposis coli protein; DP2.5; mAPC;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human APC

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton.

引用文献

Citation

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CY5641

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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