p21 CDKN1A Ab
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p21 CDKN1A Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
p21 CDKN1A Ab
Western blot analysis of p21 in (1) MCF-7 cell lysate; (2) HeLa cell lysate. (3) LnCap cell lysate; (4) U87 MG cell lysate.
p21 CDKN1A Ab
Fibulin-3 has anti-tumorigenic activities in cutaneous squamous cell carcinoma. -Journal of Investigative Dermatology
p21 CDKN1A Ab
Immunofluorescent analysis using the Antibody at 1:150 dilution.
p21 CDKN1A Ab
Immunofluorescent analysis of MCF7 cells, using p21 Antibody.
p21 CDKN1A Ab
p21 CDKN1A Ab
p21 CDKN1A Ab

产品简介

Product Introduction

Catalog No.

CY5543

Source

Recombinant Rabbit mAb

UniProt ID

P38936

Reactivity

Human;Mouse;Rat

Application

WB;ICC/IF

Calculated Mol Weight

18 kDa

Observed Mol Weight

21 kDa

Recommended Dilution

WB 1:1000-1:2000

ICC/IF 1:50-1:200

Alternative Names

CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human CDKN1A

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

The tumor suppressor protein p21 Waf1/Cip1 acts as an inhibitor of cell cycle progression. It functions in stoichiometric relationships forming heterotrimeric complexes with cyclins and cyclin-dependent kinases. In association with CDK2 complexes, it serves to inhibit kinase activity and block progression through G1/S. However, p21 may also enhance assembly and activity in complexes of CDK4 or CDK6 and cyclin D.

引用文献

Citation

Nuclear Beclin 1 Destabilizes Retinoblastoma Protein to Promote Cell Cycle Progression and Colorectal Cancer Growth

期刊名称：

Cancers

PMID：

36230664

影响因子：

6.575

应用范围：

WB

检测物种：

Human

发表时间：

2022-09-28
USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity

期刊名称：

Nature Communications

PMID：

36528652

影响因子：

17.694

应用范围：

WB,IP

检测物种：

Human

发表时间：

2022-12-17
Polystyrene nanoplastics induce haematotoxicity with cell oxeiptosis and senescence involved in C57BL/6J mice

期刊名称：

ENVIRONMENTAL TOXICOLOGY

PMID：

37466197

影响因子：

4.5

应用范围：

WB

检测物种：

Mouse

发表时间：

2023-07-19
A novel Bruton's tyrosine kinase inhibitor JDB175 shows potent efficacy to suppress central nervous system lymphoma

期刊名称：

MedComm

PMID：

37929016

影响因子：

9.9

应用范围：

WB

检测物种：

Human

发表时间：

2023-11-04
Vitexin promotes the anti-senescence effect via inhibiting JAK2/STAT3 in D-Galactose-induced progeria mice and stress-induced premature senescence

期刊名称：

EUROPEAN JOURNAL OF PHARMACOLOGY

PMID：

39084453

影响因子：

4.2

应用范围：

WB

检测物种：

Human,Mouse

发表时间：

2024-07-30

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CY5543

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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