CBX5 Ab
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CBX5 Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
CBX5 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
CBX5 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
CBX5 Ab
Western blot analysis of HP1 alpha expression in SH-SY5Y cell lysate.
CBX5 Ab
Immunofluorescent analysis using the Antibody at 1:50 dilution.
CBX5 Ab
Immunofluorescent analysis using the Antibody at 1:150 dilution.
CBX5 Ab
CBX5 Ab

产品简介

Product Introduction

Catalog No.

CY5502

Source

Recombinant Rabbit mAb

UniProt ID

P45973

Reactivity

Human;Mouse;Rat

Application

WB;IHC;ICC/IF;IHF;IP;FC

Calculated Mol Weight

22 kDa

Observed Mol Weight

22 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

ICC/IF 1:50-1:200

IHF 1:50-1:200

IP 1:20-1:50

FC 1:20-1:100

Alternative Names

CBX5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human CBX5

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

引用文献

Citation

Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transduction

期刊名称：

PLoS Pathogens

PMID：

38976714

影响因子：

5.5

应用范围：

WB,IP

检测物种：

Human

发表时间：

2024-07-08

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CY5502

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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