MLKL Ab
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MLKL Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
MLKL Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
MLKL Ab
Western blot analysis of MLKL expression in HUVEC cell lysate.
MLKL Ab
Targeting CAND1 promotes caspase-8/RIP1-dependent apoptosis in liver cancer cells. -Am J Transl Res(AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH)
MLKL Ab
Immunohistochemical analysis of paraffin-embedded human colon, using MLKL Antibody.
MLKL Ab
MLKL Ab
MLKL Ab

产品简介

Product Introduction

Catalog No.

CY5493

Source

Recombinant Rabbit mAb

UniProt ID

Q8NB16

Reactivity

Human

Application

WB;IHC

Calculated Mol Weight

54 kDa

Observed Mol Weight

54 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

Alternative Names

Mixed lineage kinase domain-like protein; hMLKL;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human MLKL

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process.Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage.

引用文献

Citation

Targeting CAND1 promotes caspase-8/RIP1-dependent apoptosis in liver cancer cells

期刊名称：

American Journal of Translational Research

PMID：

29887951

影响因子：

3.061

应用范围：

WB

检测物种：

Human

发表时间：

2018-05-15
Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway

期刊名称：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA

PMID：

35866605

影响因子：

3.511

应用范围：

WB

检测物种：

发表时间：

2022-07-25
Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells in vitro and in vivo

期刊名称：

INTERNATIONAL JOURNAL OF ONCOLOGY

PMID：

36111510

影响因子：

5.884

应用范围：

WB

检测物种：

Human

发表时间：

2022-09-15

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CY5493

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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>> All antibody products targeting this target

>> All rabbit monoclonal antibody products targeting this target