p-ERK1 (T202/Y204)/ERK2 (T185/Y187) Ab

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p-ERK1 (T202/Y204)/ERK2 (T185/Y187) Ab

Instructions

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All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.

All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.

Western blot analysis of Phospho-Erk1 (T202/Y204) + Erk2 (T185/Y187) expression in A431 cell lysate treated with EGF.

Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo. -Food & Function

Critical role for non‑GAP function of Gαs in RGS1‑mediated promotion of melanoma progression through AKT and ERK phosphorylation. -Oncology Reports

CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling. -Molecular Cancer

Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling

Introduction

Citation

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产品简介

Product Introduction

Catalog No.

CY5277

Source

Recombinant Rabbit mAb

UniProt ID

P27361/P28482

Reactivity

Human;Mouse;Rat

Application

WB;IP;ICC/IF

Calculated Mol Weight

43,41 kDa

Observed Mol Weight

42, 44 kDa

Recommended Dilution

WB 1:1000-1:2000

ICC/IF 1:50-1:200

IP 1:20-1:50

Alternative Names

ERK-1; ERK1; ERT2; kinase ERK1; MAP kinase 1; MAPK 1; MAPK3; MK03; MNK1; p44-ERK1; P44-ERK1; p44-MAPK;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Phosphorylated

Immunogen

A synthesized peptide derived from human ERK1 around the phosphorylation site of T202/Y204

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.

引用文献

Citation

Antidepressant effects of total alkaloids of Fibraurea recisa on improving corticosterone-induced apoptosis of HT-22 cells and chronic unpredictable mild stress-induced depressive-like behaviour in mice

期刊名称：

PHARMACEUTICAL BIOLOGY

PMID：

35938494

影响因子：

3.889

应用范围：

检测物种：

Mouse

发表时间：

2022-08-07

Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing

期刊名称：

Nature Communications

PMID：

36446788

影响因子：

17.694

应用范围：

检测物种：

Mouse

发表时间：

2022-11-29

CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation

期刊名称：

Cell Death & Disease

PMID：

37709757

影响因子：

应用范围：

检测物种：

Mouse

发表时间：

2023-09-14

Reactive Oxygen Species Damage Bovine Endometrial Epithelial Cells via the Cytochrome C-mPTP Pathway

期刊名称：

Antioxidants

PMID：

38136242

影响因子：

应用范围：

检测物种：

Bovine

发表时间：

2023-12-16

Impact of Air Pollutants on Lung Function and Inflammatory Response in Asthma in Shanghai

期刊名称：

BIOMEDICAL AND ENVIRONMENTAL SCIENCES

PMID：

39198247

影响因子：

应用范围：

检测物种：

Mouse

发表时间：

2024-08-20

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尾页

CY5277

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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