p-eIF2A K2 (T446) Ab

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All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.

Western blot analysis of PKR phosphorylation expression in HeLa cell lysate treated with Calyculin A and TNF-alpha.

Immunohistochemical analysis of paraffin-embedded human colon, using Phospho-PKR (T446) Antibody.

Introduction

Citation

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产品简介

Product Introduction

Catalog No.

CY5271

Source

Recombinant Rabbit mAb

UniProt ID

P19525

Reactivity

Human

Application

WB;IHC;IP;ChIP

Calculated Mol Weight

62 kDa

Observed Mol Weight

68 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

IP/ChIP 1:20-1:50

Alternative Names

E2AK2;E2AK2; EIF2AK1; EIF2AK2; MGC126524; PKR p68 kinase; PKR; PRKR;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Phosphorylated

Immunogen

A synthesized peptide derived from human eIF2A K2 around the phosphorylation site of T446

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection.

引用文献

Citation

Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity

期刊名称：

CELL

PMID：

31031002

影响因子：

36.216

应用范围：

WB,IP

检测物种：

Human

发表时间：

2019-04-25

RNA circles with minimized immunogenicity as potent PKR inhibitors

期刊名称：

MOLECULAR CELL

PMID：

34951963

影响因子：

17.97

应用范围：

检测物种：

Human

发表时间：

2021-12-23

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CY5271

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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