PMS2 Ab
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PMS2 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
PMS2 Ab
Western blot analysis of PMS2 in (1) Jurkat cell lysate; (2)HeLa cell lysate.
PMS2 Ab
Immunohistochemical analysis of paraffin-embedded human tonsil, using PMS2 Antibody.
PMS2 Ab
Immunofluorescent analysis using the Antibody at 1:50 dilution.
PMS2 Ab
Immunoprecipitate (IP) analysis using the Antibody at 1:50 dilution. (wb at 1:3K dilution)
PMS2 Ab
PMS2 Ab
PMS2 Ab

产品简介

Product Introduction

Catalog No.

CY5114

Source

Recombinant Rabbit mAb

UniProt ID

P54278

Reactivity

Human

Application

WB;IHC;ICC/IF;IHF;IP;FC

Calculated Mol Weight

96 kDa

Observed Mol Weight

120 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

ICC/IF 1:50-1:200

IHF 1:50-1:200

IP 1:20-1:50

FC 1:20-1:100

Alternative Names

DNA mismatch repair gene; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human PMS2

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.

引用文献

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CY5114

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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>> All rabbit monoclonal antibody products targeting this target