SMAD4 Ab
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SMAD4 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
SMAD4 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
SMAD4 Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
SMAD4 Ab
Western blot analysis of SMAD4 expression in (1) SH-SY5Y cell lysate; (2) NIH/3T3 cell lysate.
SMAD4 Ab
Eplerenone Prevents Atrial Fibrosis via the TGF-β Signaling Pathway. -cardiology
SMAD4 Ab
Immunohistochemical analysis of paraffin-embedded human breast cancer, using Smad4 Antibody.
SMAD4 Ab
SMAD4 Ab

产品简介

Product Introduction

Catalog No.

CY5014

Source

Recombinant Rabbit mAb

UniProt ID

Q13485

Reactivity

Human;Mouse;Rat

Application

WB;IHC

Calculated Mol Weight

60 kDa

Observed Mol Weight

65 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

Alternative Names

MAD homolog 4; MAD, mothers against decapentaplegic homolog 4; MADH4; Mothers against decapentaplegic homolog 4; DPC4; hSMAD4; JIP;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human SMAD4

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions.

引用文献

Citation

Eplerenone Prevents Atrial Fibrosis via the TGF-β Signaling Pathway

期刊名称：

CARDIOLOGY

PMID：

28571007

影响因子：

1.742

应用范围：

WB

检测物种：

Mouse

发表时间：

2017-06-02

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CY5014

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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