SMAD3 Ab
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SMAD3 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
SMAD3 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
SMAD3 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
SMAD3 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
SMAD3 Ab
Western blot analysis of Smad3 expression in (1) Jurkat cell lysate; (2) Rat liver lysate.
SMAD3 Ab
Immunohistochemical analysis of paraffin-embedded Human lung large cell cancer, using the Antibody at 1:200 dilution.
SMAD3 Ab
Immunohistochemical analysis of paraffin-embedded Human testis cancer, using the Antibody at 1:200 dilution.
SMAD3 Ab
Immunohistochemical analysis of paraffin-embedded Human breast cancer, using the Antibody at 1:200 dilution.

产品简介

Product Introduction

Catalog No.

CY5013

Source

Recombinant Rabbit mAb

UniProt ID

P84022

Reactivity

Human;Mouse;Rat

Application

WB;IHC;ICC/IF;IHF;FC

Calculated Mol Weight

48 kDa

Observed Mol Weight

55 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

ICC/IF 1:50-1:200

IHF 1:50-1:200

FC 1:20-1:100

Alternative Names

JV15-2; MADH3; Mad3; Smad 3;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human SMAD3

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription.

引用文献

Citation

Salvia miltiorrhiza Restrains Reactive Oxygen Species-Associated Pulmonary Fibrosis via Targeting Nrf2-Nox4 Redox Balance

期刊名称：

AMERICAN JOURNAL OF CHINESE MEDICINE

PMID：

31352786

影响因子：

3.51

应用范围：

IHC,WB,IP

检测物种：

Mouse

发表时间：

2019-08-15
SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion

期刊名称：

Experimental Hematology & Oncology

PMID：

33622411

影响因子：

5.133

应用范围：

WB

检测物种：

Human

发表时间：

2021-02-23
miR-744-5p suppresses tumor proliferation and metastasis by targeting transforming growth factor-beta 1 (TGF-β1) in hepatocellular carcinoma (HCC)

期刊名称：

Journal of Gastrointestinal Oncology

PMID：

34532130

影响因子：

2.892

应用范围：

WB

检测物种：

Human

发表时间：

2021-08-01
Sinomenine Relieves Airway Remodeling By Inhibiting Epithelial-Mesenchymal Transition Through Downregulating TGF-β1 and Smad3 Expression In Vitro and In Vivo

期刊名称：

Frontiers in Immunology

PMID：

34804018

影响因子：

7.561

应用范围：

IHC,WB

检测物种：

Mouse,Human

发表时间：

2021-11-05
Gamma synuclein promotes cancer metastasis through the MKK3/6-p38MAPK cascade

期刊名称：

International Journal of Biological Sciences

PMID：

35637967

影响因子：

10.75

应用范围：

WB

检测物种：

Human

发表时间：

2022-05-01

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CY5013

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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