Notch 1 Ab - Abways

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Notch 1 Ab

Instructions

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All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.

Western blot analysis of NOTCH1 expression in HEK293 cell lysate.

Immunohistochemical analysis of paraffin-embedded human liver, using Notch1 Antibody .

Immunofluorescent analysis using the Antibody at 1:50 dilution.

Immunofluorescent analysis of HeLa cells, using Notch1 Antibody .

Introduction

Citation

User feedback

产品简介

Product Introduction

Catalog No.

CY5244

Source

Recombinant Rabbit mAb

UniProt ID

P46531

Reactivity

Human;Mouse

Application

WB;IHC;ICC/IF;IHF;FC

Calculated Mol Weight

273 kDa

Observed Mol Weight

125 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

ICC/IF 1:50-1:200

IHF 1:50-1:200

FC 1:20-1:100

Alternative Names

NOTC1, NOTCH1, TAN1, hN1, neurogenic locus notch homolog protein 1, neurogenic locus notch homolog protein 1 precursor,

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human Notch 1

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.

引用文献

Citation

FSTL1 suppresses tumor cell proliferation, invasion and survival in non-small cell lung cancer

期刊名称：

ONCOLOGY REPORTS

PMID：

29115636

影响因子：

2.662

应用范围：

检测物种：

发表时间：

2017-10-31

Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage

期刊名称：

PeerJ

PMID：

36299510

影响因子：

3.061

应用范围：

检测物种：

发表时间：

2022-10-21

Activation of Notch Signaling Pathway is involved in Extracellular Matrix Degradation in Human Induced Pluripotent Stem Cells Chondrocytes Induced by HT-2 Toxin

期刊名称：

FOOD AND CHEMICAL TOXICOLOGY

PMID：

38734200

影响因子：

3.9

应用范围：

IHC,WB

检测物种：

Human

发表时间：

2024-05-10

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尾页

CY5244

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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