LGR5 Ab
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LGR5 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
LGR5 Ab
Western blot analysis of GPR49 expression in Human fetal skeletal muscle lysate.
LGR5 Ab
LGR5 Ab
LGR5 Ab
LGR5 Ab
LGR5 Ab
LGR5 Ab

产品简介

Product Introduction

Catalog No.

CY5369

Source

Recombinant Rabbit mAb

UniProt ID

O75473

Reactivity

Human;Mouse;Rat

Application

WB;IP;FC

Calculated Mol Weight

100 kDa

Observed Mol Weight

100 kDa

Recommended Dilution

WB 1:1000-1:2000

IP 1:20-1:50

FC 1:20-1:100

Alternative Names

FEX; GPR49; GPR67; GRP49; LGR5; HG38;8

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human LGR5

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.

引用文献

Citation

REC8 enhances stemness and promotes metastasis of colorectal cancer through BTK/Akt/β-catenin signaling pathway

期刊名称：

Translational Oncology

PMID：

34890967

影响因子：

4.243

应用范围：

WB,IHC

检测物种：

Mouse,Human

发表时间：

2021-12-07

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CY5369

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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