p-ERK1 (T202/Y204)/ERK2 (T185/Y187) Ab
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p-ERK1 (T202/Y204)/ERK2 (T185/Y187) Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
p-ERK1 (T202/Y204)/ERK2 (T185/Y187) Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
p-ERK1 (T202/Y204)/ERK2 (T185/Y187) Ab
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Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo. -Food & Function
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Critical role for non‑GAP function of Gαs in RGS1‑mediated promotion of melanoma progression through AKT and ERK phosphorylation. -Oncology Reports
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CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling. -Molecular Cancer
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Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling

产品简介

Product Introduction

Catalog No.

CY5277

Source

Recombinant Rabbit mAb

UniProt ID

P27361/P28482

Reactivity

Human;Mouse;Rat

Application

WB;IP;ICC/IF

Calculated Mol Weight

43,41 kDa

Observed Mol Weight

42, 44 kDa

Recommended Dilution

WB 1:1000-1:2000

ICC/IF 1:50-1:200

IP 1:20-1:50

Alternative Names

ERK-1; ERK1; ERT2; kinase ERK1; MAP kinase 1; MAPK 1; MAPK3; MK03; MNK1; p44-ERK1; P44-ERK1; p44-MAPK;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Phosphorylated

Immunogen

A synthesized peptide derived from human ERK1 around the phosphorylation site of T202/Y204

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.

引用文献

Citation

MiR-184 Combined with STC2 Promotes Endometrial Epithelial Cell Apoptosis in Dairy Goats via RAS/RAF/MEK/ERK Pathway

期刊名称：

Genes

PMID：

32906580

影响因子：

3.759

应用范围：

WB

检测物种：

Human

发表时间：

2020-09-07
USP18‑deficiency in cervical carcinoma is crucial for the malignant behavior of tumor cells in an ERK signal‑dependent manner

期刊名称：

Oncology Letters

PMID：

33850562

影响因子：

2.967

应用范围：

WB

检测物种：

Human

发表时间：

2021-03-29
CXCL3 overexpression affects the malignant behavior of oral squamous cell carcinoma cells via the MAPK signaling pathway

期刊名称：

JOURNAL OF ORAL PATHOLOGY & MEDICINE

PMID：

34392586

影响因子：

4.253

应用范围：

WB

检测物种：

Human

发表时间：

2021-08-15
Clinical significance and biological functions of chemokine CXCL3 in head and neck squamous cell carcinoma

期刊名称：

BIOSCIENCE REPORTS

PMID：

34870709

影响因子：

3.84

应用范围：

WB

检测物种：

Human

发表时间：

2021-12-22
Curcin C inhibit osteosarcoma cell line U2OS proliferation by ROS induced apoptosis, autophagy and cell cycle arrest through activating JNK signal pathway

期刊名称：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

PMID：

34896468

影响因子：

6.953

应用范围：

WB

检测物种：

Human

发表时间：

2021-12-09
FGF2 positively regulates osteoclastogenesis via activating the ERK-CREB pathway

期刊名称：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PMID：

35835230

影响因子：

4.114

应用范围：

WB

检测物种：

Mouse

发表时间：

2022-07-11

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CY5277

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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