CDKN2A Ab
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CDKN2A Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
CDKN2A Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
CDKN2A Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
CDKN2A Ab
Immunofluorescent analysis using the Antibody at 1:50 dilution.
CDKN2A Ab
CDKN2A Ab
CDKN2A Ab
CDKN2A Ab
CDKN2A Ab
CDKN2A Ab
CDKN2A Ab
CDKN2A Ab

产品简介

Product Introduction

Catalog No.

CY8312

Source

Recombinant Rabbit mAb

UniProt ID

Q8N726

Reactivity

Human

Application

WB;ICC/IF;IP;FC

Calculated Mol Weight

14 kDa

Observed Mol Weight

14 kDa

Recommended Dilution

WB 1:1000-1:2000

ICC/IF 1:50-1:200

IP 1:20-1:50

FC 1:20-1:100

Alternative Names

ARF; CDK4I; CDKN2; CDKN2A; CMM2; INK4; INK4a; MLM; MTS1; p14; p14ARF;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human CDKN2A

Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.

引用文献

Citation

Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication

期刊名称：

PLoS Pathogens

PMID：

38394330

影响因子：

5.5

应用范围：

WB

检测物种：

Pig

发表时间：

2024-02-23

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CY8312

Specifications：

50μl, 150μl

Price：

$188/50μl, $368/150μl

Delivery time：

1-4 weeks

Ordering information：

You can contact authorized dealers to purchase Abways products and obtain technical support, or you can directly contact Abways China

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