KDM1/LSD1 Antibody
Source: Monoclonal Antibodies Catalog No. : CY5517
KDM1/LSD1 Antibody (CY5517)
UniProt:O60341
Application:WB,IHC,ICC/IF,IP
Reactivity:Human,Mouse,Rat
Source:Rabbit mAbhttp://www.abways.com/showproduct.asp?cid=CY5517
Data Sheet
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UniProt
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Mol Weight110kDa
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Alternative NamesKDM1;AOF2;BHC110;KIAA0601;LSD1; KDM1A;
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ImmunogenA synthesized peptide derived from human KDM1 / LSD1
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionHistone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,IHC,ICC/IF,IP
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Recommended dilutionWB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:30
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Western blot analysis of KDM1/LSD1 expression in Hela cell lysate -
Immunohistochemical analysis of paraffin-embedded human colon, using KDM1/LSD1 Antibody.
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