STAT1 (10F1) Mouse mAb
Source: Monoclonal Antibodies  Catalog No. : AB3653 
STAT1 (10F1) Mouse mAb (AB3653)
UniProt:P42224
Application:IHC
Reactivity:Human,Mouse,Rat
Source:Mouse mAbhttp://www.abways.com/showproduct.asp?cid=AB3653
Data Sheet
  • UniProt
  • Mol Weight
    84,91kDa
  • Alternative Names
    STAT1; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84
  • Immunogen
    Synthetic peptide conjugated to KLH.
  • Storage
    Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Purification
    Affinity-chromatography
  • Isotype
    Mouse IgG1
  • Clonality
    Monoclonal
  • Description
    Swiss-Prot Acc.P42224.Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Applications
  • Reactivity
    Human,Mouse,Rat
  • Application
    IHC
  • Recommended dilution
    IHC: 1/50-1/100
  • Immunohistochemistry analysis of paraffinembedded Human Colon Tissue using STAT1 (10F1) antibody.
  • Immunohistochemical analysis of paraffinembedded human tonsils using STAT1 (10F1) antibody.
Catalog No:AB3653
  • Size:50μl, 100μl
  • Price:$185/50μl, $299/100μl
  • Delivery:3-4 days
Order Information:
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